Pfizer says data suggests COVID vaccine boosters are warranted

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Pfizer told the Food and Drug Administration on Wednesday that data from its clinical trials suggest a third shot of its coronavirus vaccine may be needed six months after the second dose as efficacy is waning.

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why it matters: On Friday, the FDA’s advisory committee is expected to review Pfizer’s clinical trials and other supporting and conflicting data on coronavirus booster shots and make recommendations on whether Americans 16 and older should receive an additional dose.

By numbers: Pfizer’s data from its trials showed that the efficacy of its coronavirus vaccine, which it developed with BioNTech, drops by about 6% every two months after the second dose, increasing the chances of success cases. Is.

  • The company said data from its analysis of success cases also suggested they were more common in people who received their second dose earlier than in others.
  • Pfizer said the decline in effectiveness was “due to a lack of immune responses to the vaccine,” not the delta version of the virus evading the protection offered by the vaccine.
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On the other end: International public health experts – including two FDA vaccine leaders who are leaving the agency this year – wrote a new paper published in The Lancet This week that booster dose isn’t necessary for the general public right now, Nerdshala’ Bob Herman reports.

  • He said current evidence suggests that vaccines are still highly effective at preventing serious illness and death from COVID-19 and that the doses used for booster shots would save more lives by vaccinating populations that are currently unvaccinated.
  • Experts favor booster shots for immunocompromised people.

big picture: The Biden administration expects to start giving everyone booster shots as soon as six months after the second dose.

  • The World Health Organization, however, currently strongly opposes developed countries offering additional doses to their general public, while developing countries struggle to procure adequate doses for their citizens.
  • WHO Director-General Tedros Adhanom Ghebreyesus last week called on developed countries to abandon booster shots by the end of the year.
  • The Biden administration has argued that additional shots are needed to stop the spread of the virus in the US and that developed countries can both administer boosters and dose to developing countries.
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go in: Israel preparing for possible second round of coronavirus booster shots

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